Methylphenidate and Amphetamine Do Not Induce Cytogenetic Damage in Lymphocytes of Children With ADHD

 This research was supported by the NIH/NICHD Best Pharmaceuticals for Children Act pediatric drug development program and the Intramural Research Program of the National Toxicology Program of the National Institute of Environmental Health Sciences.The authors thank Dr. Gregory Erexson, George Stojhovic, and Kelley Boyer for establishing, coordinating, and conducting the cytogenic analysis. The authors also thank the Duke ADHD Program psychologists for help in recruitment and enrollment, the Program's clinical trials team for assistance with the evaluation process during the screening period, and the Program's research assistants for invaluable help in the conduct of the study. The authors also thank Drs. Raymond Tice and Andrew Kligerman for fruitful discussions during preparation of this manuscript.Clinical trial registration information—Genetic Measurements in Blood Cells of Children Taking Adderall or Methylphenidate. URL: http://clinicaltrials.gov. Unique identifier: NCT00341029.

PII: S0890-8567(08)60136-7

doi: 10.1097/CHI.0b013e3181893620

© 2008 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.