Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 1 , Pages 3-6 , January 2010

A Perilous Disconnect: Antipsychotic Drug Use in Very Young Children

  • Helen Egger, M.D.

      Affiliations

    • Corresponding Author InformationCorrespondence to Helen Egger, M.D., Duke University Medical Center, Department of Psychiatry/Behavioral Sciences, DUMC Box 3454, Durham, NC 27710

,Accepted 28 October 2009.

References 

  1. Olfson M, Crystal S, Huang C, Gerhard T. Trends in antipsychotic drug use by very young, privately insured children. J Am Acad Child Adolesc Psychiatry. 2009;49:13–23
  2. Zito JM, Daniel JS, dosReis S, Gardner JF, Boles M, Lynch F. Trends in the prescribing of psychotropic medications to preschoolers. JAMA. 2000;283:1025–1030
  3. Zito JM, Safer DJ, Valluri S, Gardner JF, Korelitz JJ, Mattison DR. Psychotherapeutic medication prevalence in Medicaid-insured preschoolers. J Child Adolesc Psychopharmacol. 2007;17:195–204
  4. In:  Luby J editors. Handbook of Preschool Mental Health: Development, Disorders, and Treatment. New York: Guilford Press; 2006;
  5. In:  Zeanah CH, et al. editor. Handbook of Infant Mental Health. Third ed.. New York: Guilford Press; 2009;
  6. Egger HL, Angold A. Common emotional and behavioral disorders in preschool children: presentation, nosology, and epidemiology. J Child Psychiatry Psychol. 2006;47:313–337
  7. Kollins S, Greenhill L. Evidence base for the use of stimulant medication in preschool children with ADHD. Infants Young Child. 2006;19:132–141
  8. McCracken JT, McGough J, Shah B, et al. Risperidone in children with autism and serious behavioral problems. NEJM. 2002;347:314–321
  9. Cesena M, Gonzalez-Heydrich J, Szigethy E, Kohlenberg TM, DeMaso DR. A case series of eight aggressive young children treated with risperidone. J Child Adolesc Psychopharmacol. 2002;12:337–345
  10. Staller JA. Psychopharmacologic treatment of aggressive preschoolers: a chart review. Prog Neuro-Psychopharmacol Biol Psychiatry. 2007;31:131–135
  11. Biederman J, Mick E, Hammerness P, et al. Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children. Biol Psychiatry. 2005;58:589–594
  12. Masi G, Cosenza A, Mucci M, Brovedani P. Open trial of risperidone in 24 young children with pervasive developmental disorders. J Clin Psychiatry. 2003;64:1039–1047
  13. Masi G, Cosenza A, Mucci M, Brovedani P. A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone. J Clin Psychiatry. 2003;64:1039–1047
  14. Luby J, Mrakotsky C, Stalets MM, et al. Risperidone in preschool children with autistic spectrum disorders: an investigation of safety and efficacy. J Child Adolesc Psychopharmacol. 2006;16:575–587
  15. Posey DJ, Walsh KH, Wilson GA, McDougle CJ. Risperidone in the Treatment of two very young children with autism. J Child Adolesc Psychopharmacol. 1999;9:273–276
  16. Nicolson RMD, Awad GMD, Sloman LMD. An open trial of risperidone in young autistic children. J Am Acad Child Adolesc Psychiatry. 1998;37:372–376
  17. Correll CUMD. Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J Am Acad Child Adolesc Psychiatry. 2008;47:9–20
  18. Florida Best Practice Medication Child/Adolescent Guidelines (University of South Florida: Medicaid Drug Therapy Management Program for Behavioral Health). http://flmedicaidbh.fmhi.usf.edu/recommended_child_guidelines.htm2009;Accessed September 23, 2009
  19. Gleason MM, Egger HL, Emslie GJ, et al. Psychopharmacological treatment for very young children: contexts and guidelines. J Am Acad Child Adolesc Psychiatry. 2007;46:1532–1572

 Disclosure: Dr. Egger receives grant support from the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), the National Alliance for Research on Schizophrenia and Depression (NARSAD), the Centers for Disease Control (CDC), and Autism Speaks.

PII: S0890-8567(09)00002-1

doi: 10.1016/j.jaac.2009.10.001

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 1 , Pages 3-6 , January 2010

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