Journal of the American Academy of Child & Adolescent Psychiatry
Volume 48, Issue 7 , Pages 711-720 , July 2009

Relative Cost-Effectiveness of Treatments for Adolescent Depression: 36-Week Results From the TADS Randomized Trial

,Accepted 19 February 2009.

References 

  1. Domino ME, Burns BJ, Mario J et al. Service use and costs of care for depressed adolescents: who uses and who pays? J Clin Child Adolesc Psychol. In press.
  2. Lynch FL , Clarke GN . Estimating the economic burden of depression in children and adolescents . Am J Prev Med . 2006;31:143–151
  3. Essau C , Conradt J , Petermann F . Course and outcome of depressive disorders . In:  Essau C ,  Petermann F editor. Depressive Disorders in Children and Adolescents: Epidemiology, Course and Treatment . Northvale, NJ: Jason Aronson; 1999;p. 69–103
  4. Essau C , Dobson K . Epidemiology of depressive disorders . In:  Essau C ,  Petermann F editor. Depressive Disorders in Children and Adolescents: Epidemiology, Risk Factors, and Treatment . Northvale, NJ: Jason Aronson Press; 1999;p. 69–104
  5. Berndt ER . Lost human capital from early-onset chronic depression . Am J Psychiatry . 2000;157:940–947
  6. Keenan-Miller D , Hammen CL , Brennan PA . Health outcomes related to early adolescent depression . J Adolesc Health . 2007;41:256–262
  7. Team TT . Treatment for Adolescents with Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial . JAMA . 2004;292:807–820
  8. Team TT . The Treatment for Adolescents with Depression Study (TADS): long-term effectiveness and safety outcomes . Arch Gen Psychiatry . 2007;64:1132–1143
  9. Byford S , Barrett B , Roberts C , et al.   Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive-behavioural therapy in adolescents with major depression . Br J Psychiatry . 2007;191:521–527
  10. Domino ME , Burns BJ , Silva SG , et al.   The cost-effectiveness of treatments for adolescent depression: results from the TADS Randomized Trial . Am J Psychiatry . 2008;165:588–596
  11. Emslie G , Kratochvil C , Vitiello B , et al.   Treatment for Adolescents with Depression Study (TADS): safety results . J Am Acad Child Adolesc Psychiatry . 2006;45:1440–1455
  12. March J , Silva S , Vitiello B . The Treatment for Adolescents with Depression Study (TADS): methods and message at 12 weeks . J Am Acad Child Adolesc Psychiatry . 2006;45:1393–1403
  13. Team TT . The Treatment for Adolescents with Depression Study (TADS): demographic and clinical characteristics . J Am Acad Child Adolesc Psychiatry . 2005;44:28–40
  14. Team TT , March JS , Silva S , et al.   Treatment for Adolescents with Depression Study (TADS): rationale, design, and methods . J Am Acad Child Adolesc Psychiatry . 2003;42:531–542
  15. Poznanski EO , Mokros HB . Children_s Depression Rating Scale, Revised (CDRS-R) . Los Angeles: Western Psychological Services; 1999;
  16. Endicott J , Nee J , Yang R , Wohlberg C . The Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire (PQ-LES-Q): reliability and validity . J Am Acad Child Adolesc Psychiatry . 2006;45:401–407
  17. Gowers SG , Harrington RC , Whitton A , et al.   Brief scale for measuring the outcomes of emotional and behavioural disorders in children. Health of the Nation Outcome Scales for children and Adolescents (HoNOSCA) . Br J Psychiatry . 1999;174:413
  18. Bilenberg N . Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) . Eur Child Adolesc Psychiatry . 2003;12:298–302
  19. Garralda ME , Yates P , Higginson I . Child and adolescent mental health service use: HoNOSCA as an outcome measure . Br J Psychiatry . 2000;177:52
  20. Lave JR , Frank RG , Schulberg HC , Kamlet MS . Cost-effectiveness of treatments for major depression in primary care practice . Arch Gen Psychiatry . 1998;55:645–651
  21. Pyne JM , Tripathi S , Williams DK , Fortney J . Depression-free day to utility-weighted score: is it valid? . Med Care . 2007;45:357–362
  22. Donohue JM , Pincus HA . Reducing the societal burden of depression: a review of economic costs, quality of care and effects of treatment . Pharmacoeconomics . 2007;25:7–24
  23. Lynch FL , Hornbrook M , Clarke GN , et al.   Cost-effectiveness of an intervention to prevent depression in at-risk teens . Arch Gen Psychiatry . 2005;62:1241
  24. Schoenbaum M , Unützer J , Sherbourne C , et al.   Cost-effectiveness of practice-initiated quality improvement for depression: results of a randomized controlled trial . JAMA . 2001;11:286
  25. Wang PS , Patrick A , Avorn J , et al.   The costs and benefits of enhanced depression care to employers . Arch Gen Psychiatry . 2006;63:1345
  26. Chisholm D , Healey A , Knapp M . QALYs and mental health care . Soc Psychiatry Psychiatr Epidemiol . 1997;32:68–75
  27. Ladapo JA , Neumann PJ , Keren R , Prosser LA . Valuing children's health: a comparison of cost-utility analyses for adult and paediatric health interventions in the US . Pharmacoeconomics . 2007;25:817–828
  28. Griebsch I , Coast J , Brown J . Quality-adjusted life-years lack quality in pediatric care: a critical review of published cost-utility studies in child health . Pediatrics . 2005;115:e600–e614
  29. Prosser LA , Hammitt JK , Keren R . Measuring health preferences for use in cost-utility and cost-benefit analyses of interventions in children: theoretical and methodological considerations . Pharmacoeconomics . 2007;25:713–726
  30. Burns BJ , Angold A , Magruder-Habib K , Costello EJ , Patrick MKS . The Child and Adolescent Services Assessment (CASA) . Durham: Duke Medical Center; 1992;
  31. Royston P . Multiple imputation of missing values: update . Stata J . 2005;5:118–201
  32. Royston P . Multiple imputation of missing values . Stata J . 2004;4:227–241
  33. Little RJA , Rubin DB . Statistical Analysis with Missing Data . Hoboken: Wiley; 2002;
  34. Schafer JL . Analysis of Incomplete Multivariate Data . London: Chapman and Hall; 1997;
  35. Little RJA , Rubin DB . Statistical Analysis with Missing Data . 2nd ed.. Hoboken: John Wiley and Sons; 2002;
  36. In:  Gold MR ,  Russell LB ,  Siegel JE ,  Weinstein MC editor. Cost-Effectiveness in Health and Medicine . New York: Oxford University Press; 1996;
  37. Briggs AH , O'Brien BJ . The death of cost-minimization analysis? . Health Econ . 2001;10:179–184
  38. Hoch JS , Briggs AH , Willan AR . Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis . Health Econ . 2002;11:415–430
  39. Briggs AH , Claxton K , Sculpher MJ . Decision Modelling for Health Economic Evaluation . Oxford: Oxford University Press; 2006;
  40. Claxton K . The irrelevance of inference: a decision-making approach to the stochastic evaluation of health care technologies . J Health Econ . 1999;18:341–364
  41. Domino ME , Burns BJ , Silva SG , et al.   The cost-effectiveness of treatments for adolescent depression: results from the TADS Randomized Trial . Am J Psychiatry . 2008;165:588–596
  42. Ubel PAHR , Chernew ME , Fendrick AM . What is the price of life and why doesn't it increase at the rate of inflation? . Arch Intern Med . 2003;163:1637–1641
  43. Bridge J , Iyengar S , Salary C , et al.   Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials . JAMA . 2007;297:1683–1696
  44. Tekin E, Markowitz S. Suicidal behavior and the labor market productivity of young adults. 2005. Located at: NBER Working Papers.
  45. Kessler RC , Akiskal HS , Ames M , et al.   Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers . Am J Psychiatry . 2006;163:1561–1568

 This work was supported by contract N01 MH80008 from the National Institute of Mental Health to Duke University Medical Center (John S. March, Principal Investigator). Additional support was received by M.E.D. under K01-MH065639.Dr. Domino had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

PII: S0890-8567(09)60108-8

doi: 10.1097/CHI.0b013e3181a2b319

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 48, Issue 7 , Pages 711-720 , July 2009

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