Journal of the American Academy of Child & Adolescent Psychiatry
Volume 47, Issue 1 , Pages 68-75 , January 2008

Familial Vulnerability to ADHD Affects Activity in the Cerebellum in Addition to the Prefrontal Systems

,Accepted 2 July 2007.

REFERENCES 

  1. Castellanos FX , Tannock R . Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes . Nat Rev Neurosci . 2002;3:617–628
  2. Faraone SV , Perlis RH , Doyle AE , et al.   Molecular genetics of attention-deficit/hyperactivity disorder . Biol Psychiatry . 2005;57:1313–1323
  3. Biederman J , Faraone SV , Keenan K , et al.   Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples . Arch Gen Psychiatry . 1992;49:728–738
  4. Gottesman II , Gould TD . The endophenotype concept in psychiatry: etymology and strategic intentions . Am J Psychiatry . 2003;160:636–645
  5. Gould TD , Gottesman II . Psychiatric endophenotypes and the development of valid animal models . Genes Brain Behav . 2006;5:113–119
  6. Oosterlaan J , Logan GD , Sergeant JA . Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task . J Child Psychol Psychiatry . 1998;39:411–425
  7. Sergeant JA , Geurts H , Oosterlaan J . How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? . Behav Brain Res . 2002;130:3–28
  8. Bush G , Valera EM , Seidman LJ . Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions . Biol Psychiatry . 2005;57:1273–1284
  9. Durston S . A review of the biological bases of ADHD: what have we learned from imaging studies? . Ment Retard Dev Disabil Res Rev . 2003;i:184–195
  10. Seidman LJ , Valera EM , Makris N . Structural brain imaging of attention-deficit/hyperactivity disorder . Biol Psychiatry . 2005;57:1263–1272
  11. Durston S , Mulder M , Casey BJ , et al.   Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder . Biol Psychiatry . 2006;60:1062–1070
  12. Durston S , Fossella JA , Casey BJ , et al.   Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls . Mol Psychiatry . 2005;10:678–685
  13. Durston S , Davidson MC , Malder MJ , et al.   Dopamine-transporter-genotype conveys familial risk for ADHD through striatal activation . J Am Acad Child Adolesc Psychiatry . 2008;47:62–68
  14. Castellanos FX , Giedd JN , Marsh WL , et al.   Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder . Arch Gen Psychiatry . 1996;53:607–616
  15. Castellanos FX , Giedd JN , Berquin PC , et al.   Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder . Arch Gen Psychiatry . 2001;58:289–295
  16. Castellanos FX , Lee PP , Sharp W , et al.   Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder . JAMA . 2002;288:1740–1748
  17. Berquin PC , Giedd JN , Jacobsen LK , et al.   Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study . Neurology . 1998;50:1087–1093
  18. Durston S , Hulshoff Pol HE , Schnack HG , et al.   Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings . J Am Acad Child Adolesc Psychiatry . 2004;43:332–340
  19. Hill DE , Yeo RA , Campbell RA , et al.   Magnetic resonance imaging correlates of attention-deficit/hyperactivity disorder in children . Neuropsychology . 2003;17:496–506
  20. Mostofsky SH , Reiss AL , Lockhart P , et al.   Evaluation of cerebellar size in attention-deficit hyperactivity disorder . J Child Neurol . 1998;13:434–439
  21. Smith A , Taylor E , Rogers JW , et al.   Evidence for a pure time perception deficit in children with ADHD . J Child Psychol Psychiatry . 2002;43:529–542
  22. Rubia K , Smith AB , Brammer MJ , et al.   Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection . Neuroimage . 2003;20:351–358
  23. van Meel CS , Oosterlaan J , Heslenfeld DJ , et al.   Motivational effects on motor timing in attention-deficit/hyperactivity disorder . J Am Acad Child Adolesc Psychiatry . 2005;44:451–460
  24. Durston S , Davidson MC , Mulder MJ , et al.   Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder . J Child Psychol Psychiatry . 2007;48:881–889
  25. Wechsler D . Wechsler Intelligence Scale for Children-Revised (WISC-R) . New York: Psychological Corporation; 1974;
  26. Wechsler D . Manual for the Wechsler Intelligence Scale for Children, Third Edition (WISC-III) . San Antonio, TX: Psychological Corporation; 1991;
  27. Shaffer D , Fisher P , Lucas CP , et al.   NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses . J Am Acad Child Adolesc Psychiatry . 2000;39:28–38
  28. Davidson MC , Horvitz JC , Tottenham N , et al.   Differential cingulate and caudate activation following unexpected nonrewarding stimuli . Neuroimage . 2004;23:1039–1045
  29. Forman SD , Cohen JD , Fitzgerald M , et al.   Improved assessment ofsignificant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold . Magn Reson Med . 1995;33:636–647
  30. Brett M , Anton J-L , Valabregue R , et al.   Region of interest analysis using an SPM toolbox [abstract] . Neuroimage . 2002;16:2
  31. Pliszka SR , Glahn DC , Semrud-Clikeman M , et al.   Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment . Am J Psychiatry . 2006;163:1052–1060
  32. Smith AB , Taylor E , Brammer M , et al.   Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naïve children and adolescents with attention deficit hyperactivity disorder . Am J Psychiatry . 2006;163:1044–1051

 This work was supported by a Dutch Science Foundation (NWO) VENI grant to Dr. Durston. The authors gratefully acknowledge all of the families who participated in this study; Erno Hermans, Bas Neggers, and Vincent Kersten for hardware and software support; Matthijs Vink and Erika van Hell for running the scanner; and the clinical team at the Disruptive Disorders Clinic for their help in subject recruitment.

 Disclosure: Dr. Els van den Ban is on the advisory board of Eli Lilly Pharmaceuticals. The other authors report no conflicts of interest.

PII: S0890-8567(09)62086-4

doi: 10.1097/chi.0b013e31815a56dc

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 47, Issue 1 , Pages 68-75 , January 2008

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