Journal of the American Academy of Child & Adolescent Psychiatry
Volume 46, Issue 6 , Pages 737-746 , June 2007

Prenatal Exposure to Maternal Depression and Cortisol Influences Infant Temperament

,Accepted 8 January 2007.

REFERENCES 

  1. Antonow-Schlorke I, Schwab M, Li C, Nathanielsz PW. Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J Physiol. 2003;547:117–123
  2. Austin MP, Leader LR, Reilly N. Prenatal stress, the hypothalamic-pituitary-adrenal axis, and fetal and infant neurobehavior. Early Hum Dev. 2005;19:917–926
  3. Barker DJ. In utero programming of chronic disease. Clin Sci. 1998;95:115–128
  4. Barker DJ. Fetal programming of coronary heart disease. Trends Endocrinol Metab. 2002;13:364–368
  5. Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002;31:1235–1239
  6. Cameron N, Demerath EW. Critical periods in human growth and their relationship to diseases of aging. Am J Phys Anthropol Suppl. 2002;35:159–184
  7. Challis JR, Sloboda D, Matthews SG, et al. The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and postnatal health. Mol Cell Endocrinol. 2001;185:135–144
  8. Chapillon P, Patin V, Roy V, Vincent A, Caston J. Effects of pre- and postnatal stimulation on developmental, emotional, and cognitive aspects in rodents: a review. Dev Psychobiol. 2002;41:373–387
  9. Coe CL, Lulbach GR, Schneider ML. Prenatal disturbance alters the size of the corpus callosum in young monkeys. Dev Psychobiol. 2002;41:178–185
  10. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–396
  11. Cratty MS, Ward HE, Johnson EA, Azzaro AJ, Birkle DL. Prenatal stress increases corticotropin-releasing factor (Crf) content and release in rat amygdala minces. Brain Res. 1995;675:297–302
  12. In:  Creasy RK,  Resnik R editor. Maternal-Fetal Medicine: Principles and Practice. Philadelphia: Saunders; 1994;
  13. Culhane JF, Rauh V, McCollum KF, Hogan VK, Agnew K, Wadhwa PD. Maternal stress is associated with bacterial vaginosis in human pregnancy. Matern Child Health J. 2001;5:127–134
  14. Davis EP, Glynn LM, Dunkel Schetter C, Hobel C, Chicz-De Met A, Sandman CA. Maternal plasma corticotropin-releasing hormone levels during pregnancy are associated with infant temperament. Dev Neurosci. 2005;27:299–305
  15. Davis EP, Snidman N, Wadhwa PD, Dunkel Schetter C, Glynn L, Sandman CA. Prenatal maternal anxiety and depression predict negative behavioral reactivity in infancy. Infancy. 2004;6:319–331
  16. Davis EP, Townsend EL, Gunnar MR, et al. Effects of prenatal corticosteroid exposure on regulation of stress physiology in healthy premature infants. Psychoneuroendocrinology. 2004;29:1028–1036
  17. Davis EP, Townsend EL, Gunnar MR, et al. Antenatal betamethasone treatment has a persisting influence on infant HPA axis regulation. J Perinatol. 2006;26:147–153
  18. de Weerth C, Buitelaar J. Physiological stress reactivity in human pregnancy-a review. Neurosci Biobehav Rev. 2005;29:295–312
  19. de Weerth C, van Hees Y, Buitelaar J. Prenatal maternal cortisol levels and infant behavior during the first 5 months. Early Hum Dev. 2003;74:139–151
  20. Dickerson PA, Lally BE, Gunnel E, Birkle DL, Salm AK. Early emergence of increased fearful behavior in prenatally stressed rats. Physiol Behav. 2005;86:586–593
  21. Dunn AJ, Berridge CW. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?. Brain Res Brain Res Rev. 1990;15:71–100
  22. Gartstein MA, Rothbart MK. Studying infant temperament via the revised infant behavior questionnaire. Infant Behav Dev. 2003;26:64–86
  23. Gitau R, Cameron A, Fisk N, Glover V. Fetal exposure to maternal cortisol. Lancet. 1998;352:707–708
  24. Gitau R, Fisk N, Teixerira J, Cameron A, Glover V. Fetal hypothalamic-pituitary-adrenal stress responses to invasive procedures are independent of maternal responses. J Clin Endocrinol Metab. 2001;86:104–109
  25. Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science. 2004;305:1733–1736
  26. Goldsmith HH, Campos JJ. The structure of temperamental fear and pleasure in infants: a psychometric perspective. Child Dev. 1990;61:1944–1964
  27. Goldsmith HH, Reisner-Danner LA. Variation among temperament theories and validation studies of temperament assessment. In:  Kohnstamm GA editors. Temperament Discussed: Temperament and Development in Infancy and Childhood. Lisse, the Netherlands: Swets Zeitlinger; 1986;p. 1–9
  28. Gutteling BM, de Weerth C, Buitelaar JK. Prenatal stress and children's cortisol reaction to the first day of school. Psychoneuroendocrinology. 2005;30:541–549
  29. Hillhouse EW, Grammatopoulos DK. Role of stress peptides during human pregnancy and labour. Reproduction. 2002;124:239–323
  30. Hobel C. Stress and preterm birth. Clin Obstet Gynecol. 2004;47:856–880
  31. Hobel CJ. Identifying the patient at risk. In:  Bolognese RJ,  Schwartz RH,  Schneider J editor. Perinatal Medicine: Management of the High Risk Fetus and Neonate. Baltimore, MD: Williams & Wilkins; 1982;p. 3–28
  32. Kagan J, Snidman N, Arcus D. Childhood derivatives of high and low reactivity in infancy. Child Dev. 1998;69:1483–1493
  33. Kajantie E. Fetal origins of stress-related adult disease. Ann N Y Acad Sci. 2006;1083:11–27
  34. King BR, Nicholson RC, Smith R. Placental corticotrophin-releasing hormone, local effects and fetomaternal endocrinology. Stress. 2001;4:219–233
  35. Laplante DP, Barr RG, Brunet A, et al. Stress during pregnancy affects general intellectual and language functioning in human toddlers. Pediatr Res. 2004;56:400–410
  36. Leech SL, Larkby CA, Day R, Day NL. Predictors and correlates of high levels of depression and anxiety symptoms among children at age 10. J Am Acad Child Adolesc Psychiatry. 2006;45:223–230
  37. Lundy BL, Jones NA, Field T, et al. Prenatal depression effects on neonates. Infant Behav Dev. 1999;22:119–129
  38. Marcus SM, Flynn HA, Blow FC, Barry KL. Depressive symptoms among pregnant women screened in obstetrics settings. J Womens Health. 2003;12:373–380
  39. McCool WF, Susman EJ. Cortisol reactivity and self report anxiety in the antepartum: predictors of maternal intrapartal outcomes in gravid adolescents. J Psychosom Obstet Gynaecol. 1994;15:9–18
  40. Nathanielsz PW. Life in the Womb: The Origin of Health and Disease. Ithaca, NY: Promethean; 1999;
  41. O'Connor TG, Heron J, Golding J, Beveridge M, Glover V. Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years: report from the Avon longitudinal study of parents and children. Br J Psychiatry. 2002;180:502–508
  42. O'Connor TG, Heron J, Golding J, Glover V. Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry. 2003;44:1025–1036
  43. Owen D, Andrews MH, Matthews SG. Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour. Neurosci Biobehav Rev. 2005;29:209–226
  44. Pauli-Pott U, Mertesacker B, Bade U, Haverkock A, Beckmann D. Parental perceptions and infant temperament development. Infant Behav Dev. 2003;26:27–48
  45. Peterson BS, Anderson AW, Ehrenkranz R, et al. Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants. Pediatrics. 2003;111:939–948
  46. Petraglia F, Florio P, Nappi C, Genazzani AR. Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms. Endocr Rev. 1996;17:156–186
  47. Petraglia F, Hatch MC, Lapinski R, et al. Lack of effect of psychosocial stress on maternal corticotropin-releasing factor and catecholamine levels at 28 weeks' gestation. J Soc Gynecol Investig. 2001;8:83–88
  48. Pfeifer M, Goldsmith HH, Davidson RJ, Rickman M. Continuity and change in inhibited and uninhibited children. Child Dev. 2002;73:1474–1485
  49. Rini C, Dunkel-Schetter C, Hobel CJ, Glynn LM, Sandman CA. Effective social support: antecedents and consequences of partner support during pregnancy. Pers Relationship. 2006;13:207–229
  50. Rini CK, Dunkel-Schetter C, Wadhwa PD, Sandman CA. Psychological adaptation and birth outcomes: the role of personal resources, stress, and sociocultural context in pregnancy. Health Psychol. 1999;18:333–345
  51. Sandman CA, Glynn L, Dunkel-Schetter C, et al. Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin-releasing hormone in pregnant women: priming the placental clock. Peptides. 2006;27:1457–1463
  52. Santor DA, Coyne JC. Shortening the CES-D to improve its ability to detect cases of depression. Psychol Assess. 1997;9:233–243
  53. Schneider ML. Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants. Dev Psychobiol. 1992;25:529–540
  54. Schneider ML, Coe CL, Lubach GR. Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate. Dev Psychobiol. 1992;25:427–439
  55. Schwartz CE, Snidman N, Kagan J. Adolescent social anxiety as an outcome of inhibited temperament in childhood. J Am Acad Child Adolesc Psychiatry. 1999;38:1008–1015
  56. Schwartz CE, Wright I, Shin LM, Kagan J, Rauch SL. Inhibited and uninhibited infants grown up: adult amygdalar response to novelty. Science. 2003;300:1952–1953
  57. Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci. 2004;1032:63–84
  58. Spielberger C (1979), State-Trait Personality Inventory (STPI) Preliminary Test Manual. University of South Florida. Available at: spielber@cas.usf.edu
  59. Spielberger C. Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press; 1983;
  60. Susman EJ, Schmeelk KH, Ponirakis A, Gariepy JL. Maternal prenatal, postpartum, and concurrent stressors and temperament in 3-year-olds: a person and variable analysis. Dev Psychopathol. 2001;13:629–652
  61. Trautman PD, Meyer-Bahlburg HFL, Postelnek J, New MI. Effects of early dexamethasone on the cognitive and behavioural development of young children: results of a pilot study. Psychoneuroendocrinology. 1995;20:439–449
  62. Uno H, Eisele S, Sakai A, et al. Neurotoxicity of glucocorticoids in the primate brain. Horm Behav. 1994;28:336–348
  63. Van den Bergh BRH, Mulder EJH, Mennes M, Glover V. Antenatal maternal anxiety and stress and the neurobehavioral development of the fetus and child: links and possible mechanisms. A review. Neurosci Bio Behav Rev. 2005;29:237–258
  64. Van den Hove DLA, Blanco CE, Aendekerk B, et al. Prenatal restraint stress and long-term affective consequences. Dev Neurosci. 2005;27:313–320
  65. Ward HE, Johnson EA, Salm AK, Birkle DL. Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in the rat brain. Physiol Behav. 2000;70:359–366
  66. Weinstock M. Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog Neurobiol. 2001;65:427–451
  67. Weinstock M. The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun. 2005;19:296–308
  68. Welberg LA, Seckl J. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol. 2001;13:113–128
  69. Welberg LA, Seckl JR, Holmes MC. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience. 2001;104:71–79
  70. Worobey J, Blajda VM. Temperament ratings at 2 weeks, 2 months, and 1 year: differential stability of activity and emotionality. Dev Psychol. 1989;25:257–263
  71. Yehuda R, Engel SM, Brand S, Seckle J, Marcus S, Berkowitz G. Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. J Clin Endocrinol. 2005;90:4115–4118
  72. Zarrow MX, Philpott JE, Denenberg VH. Passage of 14-C-4 corticosterone from the rat mother to the fetus and neonate. Nature. 1970;226:1058–1059

 This research was supported by grants from NIH (HD28413, NS-41298). The authors thank the families who participated in this project.Disclosure: The authors have no financial interests to disclose.

PII: S0890-8567(09)62153-5

doi: 10.1097/chi.0b013e318047b775

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 46, Issue 6 , Pages 737-746 , June 2007