Journal of the American Academy of Child & Adolescent Psychiatry
Volume 46, Issue 7 , Pages 811-819 , July 2007

A Pilot Randomized Controlled Trial of Combined Trauma-Focused CBT and Sertraline for Childhood PTSD Symptoms

,Accepted 31 January 2007.

REFERENCES 

  1. Achenbach TM. Integrative Guide for the 1991 Child Behavior Checklist (CBCL) 4–18, YSR and TRF Profiles. Burlington: University of Vermont, Department of Psychiatry; 1991;
  2. American Academy of Child and Adolescent Psychiatry (AACAP) . Practice parameters for the assessment and treatment of children and adolescents with depressive disorders. J Am Acad Child Adolesc Psychiatry. 1998;37(suppl):635–835
  3. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory II. San Antonio, TX: Psychological Corporation; 1996;
  4. Birmaher B, Khetarpal S, Brent D, et al. The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics. J Am Acad Child Adolesc Psychiatry. 1997;36:545–554
  5. Borenstein M, Rothstein H, Cohen J. Sample Power 1.0 (software). New York: SPSS; 1997;
  6. Brady KT, Pearlstein T, Asnis GM, et al. Double-blind placebo-controlled study of the efficacy and safety of sertraline treatment of posttraumatic stress disorder. JAMA. 2000;283:1837–1844
  7. Carrion VG, Weems CF, Ray R, Reiss AL. Toward an empirical definition of pediatric PTSD: the phenomenology of PTSD symptoms in youth. J Am Acad Child Adolesc Psychiatry. 2002;41:166–173
  8. Cohen JA, Berliner L, March JS. Treatment of children and adolescents. In:  Foa EB,  Keane TM,  Friedman MY editor. Effective Treatments for PTSD. New York: Guilford; 2000;p. 106–138
  9. Cohen JA, Deblinger E, Mannarino AP, Steer R. A multisite randomized trial for sexually abused children with symptoms of posttraumatic stress disorder. J Am Acad Child Adolesc Psychiatry. 2004;43:393–402
  10. Cohen JA, Mannarino AP, Deblinger E. Treating Trauma and Traumatic Grief in Children and Adolescents. New York: Guilford; 2006;
  11. Costello EJ, Angold A. Scales to assess child and adolescent depression: checklists, screens, and nets. J Am Acad Child Adolesc Psychiatry. 1988;27:726–737
  12. Davidson JRT, Malik ML, Sutherland SM. Response characteristics to antidepressants and placebo in posttraumatic stress disorder. Int Clin Psychopharmacol. 1996;12:291–296
  13. Deblinger E, Heflin AH. Treating Sexually Abused Children and their Non-Offending Parents: A Cognitive Behavioral Approach. Thousand Oaks, CA: Sage; 1996;
  14. Foa EB, Treadwell K, Johnson K, Feeny NC. The Child PTSD Symptom Scale: a preliminary examination of its psychometric properties. J Clin Child Psychol. 2001;30:376–384
  15. Green B, Shirk S, Hanze D, Wansrath J. The Children's Global Assessment Scale in clinical practice: an empirical evaluation. J Am Acad Child Adolesc Psychiatry. 1994;33:1158–1164
  16. Griffin LD, Mellon SH. Selective serotonin reuptake inhibitors directly alter activity of neuroteroidogenic enzymes. Proc Natl Acad Sci U S A. 1999;96:13512–13517
  17. Kaufman J, Birmaher B, Brent DA, et al. Schedule for Affective Disorders and Schizophrenia for School-Aged Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1996;36:980–988
  18. Klein RG (1998), Side Effects Form for Children and Adolescents. New York: New York State Psychiatric Institute. Available from rklein@mssm.edu
  19. Leon AC. Placebo protects subjects from nonresponse: a paradox of power. Arch Gen Psychiatry. 2000;57:329–330
  20. Mannarino AP, Cohen JA. Family-related variable and psychological symptom formation in sexually abused girls. J Child Sex Abuse. 1996;5:105–119
  21. Mannarino AP, Cohen JA, Berman SR. Children's Attributions and Perceptions Scale: a new measure of child sexual abuse-related factors. J Clin Child Psychol. 1994;23:204–211
  22. Mitka M. FDA alert on antidepressants for youth. JAMA. 2003;290:2534
  23. Quitkin FM, Klein DF. What conditions are necessary to assess antidepressant efficacy?. Arch Gen Psychiatry. 2000;57:323–324
  24. Saunders BE, Berliner L, Hanson RF (2004), Department of Justice Office of Victims of Crime Treatment Guidelines for Sexually and Physically Abused Children. Available at: www.musc.edu/cvc. Accessed February 7, 2007
  25. Schreiber R, Melon C, DeVry J. The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test. Psychopharmacology. 1998;135:383–391
  26. Shaffer D, Gould MS, Brasic J, et al. A Children's Global Assessment Scale (CGAS). Arch Gen Psychiatry. 1983;40:1228–1231
  27. TF-CBT Web (2005) A Web based learning course for Trauma-Focused Cognitive Behavioral Therapy. Available at: www.musc.edu/tfcbt. Accessed February 23, 2007
  28. U.S. Food and Drug Administration (2004), FDA launches a multi-pronged strategy to strengthen safeguards for children treated with antidepressant medications. FDA News: October 15
  29. van der Kolk BA, Dreyfuss D, Michaels M, et al. Fluoxetine in posttraumatic stress disorder. J Clin Psychiatry. 1994;55:517–522
  30. Walker EA, Unutzer J, Rutter C, et al. Costs of health care use by women HMO members with a history of childhood abuse and neglect. Arch Gen Psychiatry. 1999;56:609–613
  31. Warshaw MG, Fierman E, Pratt D, et al. Quality of life and dissociation in anxiety disordered patients with histories of trauma or PTSD. Am J Psychiatry. 1993;150:1512–1516

 This project was funded by an Independent Scientist grant from the National Institute of Mental Health (K02MH01938) to Dr. Cohen. Sertraline tablets and identical pill placebo were donated to this project by Pfizer. The authors thank the project therapists, research coordinator, independent evaluator, and consultants for their assistance, as well as Jeffrey Bridge, Ph.D., Rachel San Pedro, M.S.W., and Ann Marie Kotlik for their many contributions to this project. Most of all, they thank the children and parents who participated in this project.Disclosure: The authors have no financial relationships to disclose.

PII: S0890-8567(09)62169-9

doi: 10.1097/chi.0b013e3180547105

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 46, Issue 7 , Pages 811-819 , July 2007

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