Journal of the American Academy of Child & Adolescent Psychiatry
Volume 34, Issue 4 , Pages 472-476, April 1995

Case Study: Antimanic Effectiveness of Dextroamphetamine in a Brain-Injured Adolescent

Dr. Max is Assistant Professor, University of Iowa, Iowa City. Drs. Richards and Hamdan-Allen are in private practice in Cedar Rapids and Iowa City, respectively

Accepted 22 November 1994.

ABSTRACT 

A relatively enduring and counterintuitive antimanic response to dextroamphetamine in a brain-injured adolescent who had failed trials involving divalproex, lithium, haloperidol, and carbamazepine is described. This finding combined with data from previous reports of antimanic effects of test doses of stimulants imply that such a pharmacological probe may prove relevant for the prediction of treatment response of mania to dextroamphetamine and perhaps for subclassification of bipolar disorder.

Key Words:  dextroamphetamine , adolescents , bipolar disorder , secondary mania

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 The authors thank Robert G. Robinson, M.D., for his helpful comments during manuscript preparation; Yutaka Sato, M.D., and Wilbur Smith, M.D., for interpretation of the neuroimaging; and Samuel Kuperman, M.D., for the graphics.

PII: S0890-8567(09)63733-3

doi:10.1097/00004583-199504000-00014

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 34, Issue 4 , Pages 472-476, April 1995

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