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Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 4
, Pages 345-355
, April 2010
Beyond the Dual Pathway Model: Evidence for the Dissociation of Timing, Inhibitory, and Delay-Related Impairments in Attention-Deficit/Hyperactivity Disorder
References
- . Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: the state of the field and salient challenges for the coming decade. Biol Psychiatry. 2005;57:1424–1435
- . Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry. 2005;57:1336–1346
- . Inhibitory Deficits in Attention Deficit Hyperactivity Disorder are Independent of Basic Processing Efficiency and IQ. J Neur Trans. 2008;115:261–268
- . Hyperactivity in boys with attention-deficit/hyperactivity disorder (ADHD): a ubiquitous core symptom or manifestation of working memory deficits?. J Abnorm Child Psychol. 2009;37:521–534
- Colour perception in ADHD. J Child Psychol Psychiatry. 2006;47:568–572
- . The neuropsychological effects of chronic methylphenidate on drug-naïve boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2007;62:954–962
- . Temporal information processing in ADHD: findings to date and new methods. J Neurosci Methods. 2006;151:15–29
- . The impact of reinforcement contingencies on AD/HD: a review and theoretical appraisal. Clin Psychol Rev. 2005;25:183–213
- . How clinically functional are executive function measures of ADHD?. In: Shaffer D, Leibenluft E, Rohde LA, Sirovatka P, Regier DA editor. Externalizing Disorders of Childhood: Refining the Research Agenda for DSM-V. Arlington, VA: American Psychiatric Association; 2007;
- . Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes?. Biol Psychiatry. 2005;57:1224–1230
- . Executive dysfunction and delay aversion in ADHD: nosological and diagnostic implications. Child Adolesc Psychiatr Clin North Am. 2008;17:367–384
- . Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition. Behav Brain Res. 2002;130:29–36
- . The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics. Neurosci Biobehav Rev. 2003;27:593–604
- . Causal models of attention-deficit/hyperactiviy disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry. 2005;57:1231–1238
- Delay and choice in ADHD: a test of the delay aversion hypothesis. Neuropsychology. 2009;23:367–380
- The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multimodal treatment study of AD/HD. J Abnorm Child Psychol. 2001;29:215–228
- . AD/HD and the capture of attention by briefly exposed delay-related cues: evidence from a conditioning paradigm. J Chid Psychol Psychiatry. 2003;44:1–11
- . Do delay aversion and executive function deficits make distinct contributions to the functional impact of ADHD symptoms? (A study of early academic skill deficits). J Child Psychol Psychiatry. 2007;14:1061–1070
- . Delay and inhibition as early predictors of ADHD symptoms in third grade. J Abnorm Child Psychol. 2009;37:1–15
- . Delay aversion: effects of 7-OH-DPAT, 5-HT1A/B-receptor stimulation and D-cycloserine. Pharmacol Biochem Behav. 2006;85:736–743
- . Heterogeneity in ADHD: neuropsycholgical pathways, comorbidity and symptom domain. J Abnorm Child Psychol. 2009;37:551–564
- Cerebellar magnetic stimulation decreases-inducd dyskinesias in Parkinson disease. Neurology. 2009;73:113–119
- . Common neural mechanisms for explicit timing in the sub-second range. Neuroreport. 2009;20:897–901
- . Developmental changes in neural activation and psychphysiological interaction patterns of brain regions associated with interference control and time perception. Neuroimage. 2008;43:399–409
- . Time perception deficits in attention-deficit/hyperactivity disorder and comorbid reading difficulties in child and adolescent samples. J Child Psychol Psychiatry. 2003;44:888–903
- . Sense of time in children with ADHD: effects of duration, distraction, and stimulant medication. J Internat Neuropsychol Soc. 1997;3:359–369
- . Time perception and reproduction in young adults with attention deficit hyperactivity disorder. Neuropsychology. 2001;15:351–360
- . Time reproduction in children with ADHD and their nonaffected siblings. J Am Child Adolesc Psychiatry. 2007;46:582–590
- . Motor timing deficits in community and clinical boys with hyperactivity behavior: the effect of methylphenidate on motor timing. J Abn Child Psychol. 2003;31:301–313
- . Evidence for a pure time perception deficit in children with ADHD. J Child Psychol Psychiatry. 2002;43:529–542
- Time perception deficit in children with ADHD. Brain Res. 2009;1170:90–96
- . Abnormal rhythmic motor response in children with attention-deficit-hyperactivity disorder. Dev Med Child Neurol. 2003;45:743–745
- Speed, variability, and timing on motor output in ADHD: which measures are useful for endophenotypic research?. Behav Gen. 2008;38:121–132
- . Synchronization, anticipation, and consistency in motor timing of children with dimensionally defined attention deficit hyperactivity behavior. Percept Mot Skills. 1999;89:1237–1258
- . Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normaliztion iwht methylphenidate. Phil Trans R Soc Lond B Biol Sci. 2009;364:1919–1931
- . Whither causal models in the neuroscience of ADHD?. Dev Sci. 2005;8:105–114
- Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychol Rev. 2007;17:39–59
- . The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–645
- . Statistical approaches to complex phenotypes: evaluating neuropsychological endophenotypes for attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1347–1356
- Inhibition of motor responses in siblings concordant and discordant for attention deficit hyperactivity disorder. Am J Psychiatry. 2005;162:1076–1082
- . Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychol Med. 2008;38:1595–1606
- Duration discrimination in the range of milliseconds and seconds in children with ADHD and their unaffected siblings. Psychol Med. 2009;6:1–7
- . Motor flexibility problems as a marker for genetic susceptibility to ADHD. Biol Psychiatry. 2005;58:233–238
- . Delay aversion in attention deficit/hyperactivity disorder (ADHD): an empirical investigation of the broader phenotype. Neuropsychologia. 2009;47:446–456
- . Tapping and anticipation performance in attention deficit hyperactivity disorder. Percept Mot Skills. 2005;100:659–675
- . Sense of time and executive functioning in children and adults. Child Neuropsychol. 2008;14:372–386
- . Behavioural inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997;121:65–94
- . Cognitive inhibition and working memory in attention-deficit hyperactivity disorder. J Abnorm Psychol. 2008;117:591–605
- . Cerebellar function, dyslexia and articulation speed. Child Neuropsychol. 2008;14:303–313
- . The relationship between motor control and phonology in dyslexic children. J Child Psychol Psychiatry. 2003;44:712–722
- The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry. 2006;11:934–953
- . The epidemiology of childhood hyperactivity. Maudsley Monograph No. 33 Oxford: Oxford University Press; 1991;
- . The Strengths and Difficulties Questionnaire: a research note. J Child Psychol Psychiatry. 1997;38:581–586
- . Impulsivity and inhibitory control. Psychol Sci. 1997;8:60–64
- . Maturation of action monitoring from adolescents to adulthood: an ERP study. Dev Sci. 2005;8:525–534
- . Psychological mechanisms in hyperactivity: I. Response inhibition deficit, working memory impairment, delay aversion, or something else?. J Child Psychol Psychiatry. 2001;42:199–210
- . Probing the limits of delay intolerance: preliminary young adult data from the Delay Frustration Task (DeFT). J Neurosci Methods. 2006;151:38–44
- . The effect of delay on hyperactive and non-hyperactive children's response times: a research note. J Child Psychol Psychiatry. 1992;33:1091–1096
- . Sequential estimation of points on a psychological function. Br J Math Stat Psychol. 1965;18:1–10
- . Wechsler Intelligence Scale for Children. (3rd ed.). San Antonio, TX: Psychological Corporation; 1991;
- . Test of word reading efficacy (TOWRE). Austin, TX: Pro-ed; 1999;
- . Assessment of children: WISC-III and WPPSI-R Supplement. San Diego, CA: J. M. Sattler; 1992;
- . Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder. Biol Psychiatry. 2007;62:991–998
- . Evaluating the endophenotype model of ADHD neuropsychological deficit: results for parents and siblings of children with DSM-IV ADHD combined and inattentive subtypes. J Abnorm Psychol. 2004;113:614–625
- . Deficient response inhibition as a cognitive endophenotype of ADHD. J Am Acad Child Adolesc Psychiatry. 2003;42:1242–1248
- . The adrenergic receptor α-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD. Cogn Aff Behav Neurosci. 2006;6:18–30
- . Neuropsychological functioning in relatives of girls with and without ADHD. Psychol Med. 2005;35:1121–1132
- Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects. Psychol Med. 2007;31:1–13
- . Reaction time, inhibition, working memory and ‘delay aversion' performance: genetic influences and their interpretation. Psychol Med. 2006;36:613–1624
- . Context dependent dynamic models of attention deficit/hyperactivity disorder: differentiating common and unique elements of the state regulation deficit and delay aversion models. Neuropsychol Rev. 2009;In press
- . Cognitive training for attention, inhibition and working memory deficits: a potential treatment for ADHD?. Advanc ADHD. 2009;3:89–96
This research was funded in part by ESRC CASE Award PTA-033-2003-00046 with Eli Lilley Ltd (to E.S.-B. and M.T. for P.B.).
Clinical data from the participants included in this paper contributed to the IMAGE project (Faraone; National Institutes of Health grant R01 MH62873-01A1).
Disclosure: Dr. Sonuga-Barke has served on the speakers' bureau and as a consultant for Shire and UCB Pharma. He has received research support from Janssen Cilag, Shire, Qbtech, and Flynn Pharma. He has served on the advisory board for Shire, Flynn Pharma, UCB Pharma, and Astra Zeneca. He has received conference support from Shire. Dr. Thompson has received education sponsorship from Eli Lilly and Janssen Cilag. She has received unrestricted research grants from Eli Lilly, Janssen Cilag, UCB Pharma, and Shire. She has served on the advisory board for Eli Lilly, UCB Pharma, and Shire. She has received drug trial support from Eli Lilly and Janssen Cilag. She has received lecture fees from Eli Lilly and Janssen Cilag. She has received funding for the support of Ph.D. students from Eli Lilly and Janssen Cilag. Dr. Bitsakou reports no biomedical financial interests or potential conflicts of interest.
PII: S0890-8567(10)00074-2
doi: 10.1016/j.jaac.2009.12.018
© 2010 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
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Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 4
, Pages 345-355
, April 2010
