Volume 49, Issue 8 , Pages 772-782, August 2010
Imaging–Genetics Applications in Child Psychiatry
Objective
To place imaging–genetics research in the context of child psychiatry.
Method
A conceptual overview is provided, followed by discussion of specific research examples.
Results
Imaging–genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.
Conclusions
Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.
Key Words: imaging, genetics, anxiety, children and adolescents
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This article is discussed in an editorial by Drs. James J. Hudziak and Stephen V. Faraone on page 729.
This article was reviewed under and accepted by Ad Hoc Editor David R. Rosenberg, M.D.
This is one of several articles published in the August and September issues of the Journal of the American Academy of Child and Adolescent Psychiatry that explores the intersection of genetics and mental health disorders in children and adolescents. The editors invite the reader to investigate the additional articles on this burgeoning area of developmental psychopathology.
Disclosure: Drs. Pine, Ernst, and Leibenluft report no biomedical financial interests or potential conflicts of interest.
PII: S0890-8567(10)00107-3
doi:10.1016/j.jaac.2009.12.022
© 2010 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
Volume 49, Issue 8 , Pages 772-782, August 2010
