Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 9 , Pages 906-920 , September 2010

Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder

  • Benjamin M. Neale, Ph.D.

      Affiliations

    • Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA
    • Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA
    • ,
  • Sarah Medland, Ph.D.

      Affiliations

    • Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    • Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA
    • ,
  • Stephan Ripke, M.D.

      Affiliations

    • Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA
    • Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA
    • ,
  • Richard J.L. Anney, Ph.D.

      Affiliations

    • Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland
    • ,
  • Philip Asherson, M.R.C.Psych., Ph.D.

      Affiliations

    • Medical Research Council Social Genetic and Developmental Psychiatry, Kings's College London, United Kingdom
    • ,
  • Jan Buitelaar, M.D.

      Affiliations

    • Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
    • ,
  • Barbara Franke, Ph.D.

      Affiliations

    • Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
    • ,
  • Michael Gill, M.B., Bch, BAO, M.D., MRCPsych, F.T.C.D.

      Affiliations

    • Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland
    • ,
  • Lindsey Kent, M.D., Ph.D.

      Affiliations

    • Bute Medical School, St. Andrews, Scotland, United Kingdom
    • ,
  • Peter Holmans, Ph.D.

      Affiliations

    • Medical Research Council Social Genetic and Developmental Psychiatry, Kings's College London, United Kingdom
    • ,
  • Frank Middleton, Ph.D.

      Affiliations

    • State University of New York Upstate Medical University, Syracuse, NY
    • ,
  • Anita Thapar, M.D.

      Affiliations

    • Medical Research Council Centre in Neuropsychiatric Genetics and Genomics Cardiff University School of Medicine Cardiff, UK
    • ,
  • Klaus-Peter Lesch, M.D.

      Affiliations

    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Stephen V. Faraone, Ph.D.

      Affiliations

    • State University of New York Upstate Medical University, Syracuse, NY
    • Corresponding Author InformationCorresponding author: Stephen V. Faraone, Ph.D., Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210
    • ,
  • Mark Daly, Ph.D.

      Affiliations

    • Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA
    • Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA
    • ,
  • Thuy Trang Nguyen, Dipl. Math. oec

      Affiliations

    • Institut fuer Med. Biometrie und Epidemiologie, Philipps-Universitaet Marburg, Marburg, Germany
    • ,
  • Helmut Schäfer, Ph.D.

      Affiliations

    • Institut fuer Med. Biometrie und Epidemiologie, Philipps-Universitaet Marburg, Marburg, Germany
    • ,
  • Hans-Christoph Steinhausen, M.D., Ph.D., D.M.Sc.

      Affiliations

    • University of Zurich, Zurich, Switzerland
    • ,
  • Andreas Reif, M.D.

      Affiliations

    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Tobias J. Renner, M.D.

      Affiliations

    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Marcel Romanos, M.D.

      Affiliations

    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Jasmin Romanos, M.D.

      Affiliations

    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Andreas Warnke, M.D., Ph.D.

      Affiliations

    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Susanne Walitza, M.D.

      Affiliations

    • University of Zurich, Zurich, Switzerland
    • University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Christine Freitag, M.D., M.A.

      Affiliations

    • JW Goethe University, Frankfurt am Main, Germany
    • ,
  • Jobst Meyer, Ph.D.

      Affiliations

    • Institute of Psychobiology, University of Trier, Trier, Germany
    • ,
  • Haukur Palmason, Ph.D.

      Affiliations

    • Institute of Psychobiology, University of Trier, Trier, Germany
    • ,
  • Aribert Rothenberger, M.D., Ph.D.

      Affiliations

    • University of Goettingen, Germany
    • ,
  • Ziarih Hawi

      Affiliations

    • Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland
    • ,
  • Joseph Sergeant, Ph.D.

      Affiliations

    • Vrije Universiteit, De Boelelaan, Amsterdam, the Netherlands
    • ,
  • Herbert Roeyers, M.D., Ph.D.

      Affiliations

    • Ghent University, Dunantlaan, Ghent, Belgium
    • ,
  • Eric Mick, Sc.D.

      Affiliations

    • Harvard Medical School, Massachusetts General Hospital, Boston, MA
    • ,
  • Joseph Biederman, M.D.

      Affiliations

    • Harvard Medical School, Massachusetts General Hospital, Boston, MA
    • Clinical and Research Program in Pediatric Psychopharmacology Adult ADHD at Massachusetts General Hospital
    • ,
  • IMAGE II Consortium

,Accepted 10 June 2010.

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 This article is discussed in an editorial by Drs. James J. Hudziak and Stephen V. Faraone on page 729 of the August 2010 issue.

 This article was reviewed under and accepted by Ad Hoc Editor Robert Althoff, M.D., Ph.D.

 This work was supported by the following grants: US National Institutes of Health grants R13MH059126, R01MH62873, U01MH085518, and R01MH081803 to S.V. Faraone; Affymetrix Power Award, 2007, to B. Franke; NHMRC (Australia); a Sidney Sax Public Health Fellowship (443036) to S.E. Medland; Wellcome Trust, UK to L. Kent; an Internal Grant of Radboud University Nijmegen Medical Centre to J. Buitelaar; a Wellcome Trust, UK, grant to A. Thapar, M. O'Donovan, and M. Owen; Deutsche Forschungsgemeinschaft grant KFO 125 to K.P. Lesch and A. Reif; SFB 581 and GRK 1156 to K.P. Lesch; RE 1632/5-1 to A. Reif; SFB TRR58 to K.P. Lesch and A. Reif; ME 1923/5-1 and ME 1923/5-3 to C. Freitag and J. Meyer; SCHA 542/10-3 to H. Schäfer; and the Bundesministerium für Bildung und Forschung BMBF grant 01GV0605 to K.P. Lesch.

 This article is one of several articles published in the August and September issues of the Journal of the American Academy of Child and Adolescent Psychiatry that explores the intersection of genetics and mental health disorders in children and adolescents. The editors invite the reader to investigate the additional articles on this burgeoning area of developmental psychopathology.

 The IMAGE II Consortium consists of: Writing Team: Benjamin M. Neale, Ph.D. (coleader), Sarah Medland, Ph.D. (coleader), Stephan Ripke, M.D., Richard J.L. Anney, Ph.D., Philip Asherson, M.R.C.Psych., Ph.D., Jan Buitelaar, M.D., Barbara Franke, Ph.D., Michael Gill, Mb. B.Ch. BAO, M.D., M.R.C.Psych., F.T.C.D., Lindsey Kent, M.D., Ph.D., Peter Holmans, Ph.D., Frank Middleton, Ph.D., Anita Thapar, M.D., Klaus-Peter Lesch, M.D., Stephen V. Faraone, Ph.D. (chair); Data Management and Analysis Team: Stephan Ripke, M.D. (coleader), Sarah Medland, Ph.D. (coleader), Richard J.L. Anney, Ph.D., Mark Daly, Ph.D., Thuy Trang Nguyen, Dipl. Math. oec, Helmut Schäfer, Ph.D., Benjamin M. Neale, Ph.D. (chair); Genotyping Team: Frank Middleton, Ph.D. (chair); Data Collection Team: Hans-Christoph Steinhausen, M.D., Ph.D., D.M.Sc., Klaus-Peter Lesch, M.D., Andreas Reif, M.D., Tobias J. Renner, M.D., Marcel Romanos, M.D., Jasmin Romanos, M.D., Andreas Warnke, M.D., Ph.D., Susanne Walitza, M.D., Thuy Trang Nguyen, Dipl. Math. oec, Helmut Schäfer, Ph.D., Christine Freitag, M.D., M.A., Jobst Meyer, Ph.D., Haukur Palmason, Ph.D., Aribert Rothenberger, M.D., Ph.D., Jan Buitelaar, M.D., Barbara Franke, Ph.D., Michael Gill, Mb. B.Ch. B.A.O., M.D., M.R.C.Psych., F.T.C.D., Richard J.L. Anney, Ph.D., Ziarih Hawi, Anita Thapar, M.D., Lindsey Kent, M.D., Ph.D., Joseph Sergeant, Ph.D., Herbert Roeyers, M.D., Ph.D., Philip Asherson, M.R.C.Psych., Ph.D., Eric Mick, Sc.D., Stephen V. Faraone, Ph.D., Joseph Biederman, M.D., Stephen V. Faraone, Ph.D. (chair); and Statistical Expert: Benjamin M. Neale, Ph.D.

 Disclosure: Dr. Buitelaar has, in the past three years, served as a consultant to, member of the advisory board, and/or served on the speakers' bureau for Janssen Cilag BV, Eli Lilly and Co., Bristol-Myers Squibb, Organon/Shering Plough, UCB, Shire, Medice, Servier, and Servier. Dr. Faraone has, in the past year, received consulting fees and has served on advisory boards for Eli Lilly and Co., Ortho-McNeil, and Shire Development, and has received research support from Eli Lilly and Co., Pfizer, Shire, and the National Institutes of Health. In previous years, Dr. Faraone has received consulting fees, served on advisory boards, or been a speaker for Shire, McNeil, Janssen, Novartis, Pfizer, and Eli Lilly and Co. In previous years he has received research support from Eli Lilly and Co., Shire, Pfizer and the National Institutes of Health. Dr. M. Romanos, in the past three years, has served on the speakers' bureau for Janssen-Cilag. In previous years he has served on the speakers' bureau for MEDICE. Dr. Freitag, in the past three years, has served on the speakers' bureau for Eli Lilly and Co., Shire, Novartis, and Janssen-Cilag. Dr. Mick receives research support from Ortho-McNeil Janssen Scientific Affairs, Pfizer, Shire Pharmaceuticals, and has been an advisory board member for Shire Pharmaceuticals. Dr. Biederman receives research support from Alza, AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Co., Janssen Pharmaceuticals Inc., McNeil, Merck, Organon, Otsuka, Shire, the National Institute of Mental Health, and the National Institute of Child Health and Human Development. In 2009, Dr. Biederman served on the speakers' bureau for Fundacion Areces, Medice Pharmaceuticals, and the Spanish Child Psychiatry Association. In previous years, Dr. Biederman has received research support, consultation fees, or speakers' fees for/from Abbott, AstraZeneca, Celltech, Cephalon, Eli Lilly and Co., Esai, Forest, Glaxo, Gliatech, Janssen, McNeil, the National Alliance for Research on Schizophrenia and Depression, the National Institute on Drug Abuse, New River, Novartis, Noven, Neurosearch, Pfizer, Pharmacia, The Prechter Foundation, Shire, The Stanley Foundation, UCB Pharma, Inc. and Wyeth. Dr. Sergeant has served on the advisory boards for Eli Lilly and Co. and Shire. He has received research grant support from Eli Lilly and Co. and served on the speakers' bureau for Shire, Eli Lilly and Co., Janssen-Cilag, and Novartis. Dr. Schäfer has served as a consultant for Daiichi Sankyo, served on the speakers' bureau for the European School of Oncology, and receives research grants from the German Federal Government, and the German Research Foundation. Drs. Neale, Medland, Ripke, Anney, Asherson, Franke, Gill, Kent, Holmans, Middleton, Thapar, Lesch, Daly, Nguyen, Steinhausen, Reif, Renner, J. Romanos, Warnke, Walitza, Meyer, Palmason, Rothenberger, Hawi, and Roeyers report no biomedical financial interests or potential conflicts of interest.

PII: S0890-8567(10)00482-X

doi: 10.1016/j.jaac.2010.06.007

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 9 , Pages 906-920 , September 2010

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