Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 10 , Pages 1011-1023 , October 2010

Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors

  • Nao J. Gamo, M.Phil.
    • ,
  • Min Wang, Ph.D.
    • ,
  • Amy F.T. Arnsten, Ph.D.

      Affiliations

    • Corresponding Author InformationCorrespondence to Amy F.T. Arnsten, Ph.D., Department of Neurobiology, Yale Medical School, 333 Cedar St., New Haven, CT 06510

,Accepted 29 June 2010.

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 This article is discussed in an editorial by Dr. F. Xavier Castellanos on page 977.

 This article was reviewed under and accepted by Associate Editor James J. Hudziak, M.D.

 This research was supported by a grant from Shire Pharmaceuticals to Dr. Arnsten as part of an overarching goal to further understanding of the neurobiological bases of ADHD and its treatment.

 Disclosure: Dr. Arnsten and Yale University have a license agreement and receive royalties from Shire Pharmaceuticals for the development of guanfacine (Intuniv™) for the treatment of ADHD and related disorders. Dr. Arnsten also performs consulting, teaching, and speaking engagements for Shire Pharmaceuticals. Dr. Arnsten has provided consultation to Eli Lilly and Co. in the past but not in regard to the present research. Dr. Gamo previously owned stock in Shire Pharmaceuticals but has since divested. Dr. Wang reports no biomedical financial interests or potential conflicts of interest.

PII: S0890-8567(10)00522-8

doi: 10.1016/j.jaac.2010.06.015

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 49, Issue 10 , Pages 1011-1023 , October 2010

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