Journal of the American Academy of Child & Adolescent Psychiatry
Volume 50, Issue 3 , Pages 216-231.e3, March 2011

Validity of Evidence-Derived Criteria for Reactive Attachment Disorder: Indiscriminately Social/Disinhibited and Emotionally Withdrawn/Inhibited Types

  • Mary Margaret Gleason, M.D.

      Affiliations

    • Tulane University School of Medicine
    • Corresponding Author InformationCorrespondence to Mary Margaret Gleason, M.D., Department of Psychiatry and Behavioral Sciences, 1440 Canal Street TB 52, New Orleans, LA 70112
  • ,
  • Nathan A. Fox, Ph.D.

      Affiliations

    • University of Maryland
  • ,
  • Stacy Drury, M.D., Ph.D.

      Affiliations

    • Tulane University School of Medicine
  • ,
  • Anna Smyke, Ph.D.

      Affiliations

    • Tulane University School of Medicine
  • ,
  • Helen L. Egger, M.D.

      Affiliations

    • Duke University Medical Center
  • ,
  • Charles A. Nelson III, Ph.D.

      Affiliations

    • Harvard Medical School
  • ,
  • Matthew C. Gregas, Ph.D.

      Affiliations

    • Harvard Medical School
  • ,
  • Charles H. Zeanah, M.D.

      Affiliations

    • Tulane University School of Medicine

Accepted 20 December 2010. published online 31 January 2011.

Objective

This study examined the validity of criteria for indiscriminately social/disinhibited and emotionally withdrawn/inhibited reactive attachment disorder (RAD).

Method

As part of a longitudinal intervention trial of previously institutionalized children, caregiver interviews and direct observational measurements provided continuous and categorical data used to examine the internal consistency, criterion validity, construct validity, convergent and discriminant validity, association with functional impairment, and stability of these disorders over time.

Results

As in other studies, the findings showed distinctions between the two types of RAD. Evidence-derived criteria for both types of RAD showed acceptable internal consistency and criterion validity. In this study, rates of indiscriminately social/disinhibited RAD at baseline and at 30, 42, and 54 months were 41/129 (31.8%), 22/122 (17.9%), 22/122 (18.0%), and 22/125 (17.6%), respectively. Signs of indiscriminately social/disinhibited RAD showed little association with caregiving quality. Nearly half of children with indiscriminately social/disinhibited RAD had organized attachment classifications. Signs of indiscriminately social/disinhibited RAD were associated with signs of activity/impulsivity and of attention-deficit/hyperactivity disorder and modestly with inhibitory control but were distinct from the diagnosis of attention-deficit/hyperactivity disorder. At baseline, 30, 42, and 54 months, 6/130 (4.6%), 4/123 (3.3%), 2/125 (1.6%), and 5/122 (4.1%) of children met criteria for emotionally withdrawn/inhibited RAD. Emotionally withdrawn/inhibited RAD was moderately associated with caregiving at the first three time points and strongly associated with attachment security. Signs of this type of RAD were associated with depressive symptoms, although two of the five children with this type of RAD at 54 months did not meet criteria for major depressive disorder. Signs of both types of RAD contributed independently to functional impairment and were stable over time.

Conclusions

Evidence-derived criteria for indiscriminately social/disinhibited and emotionally withdrawn/inhibited RAD define two statistically and clinically cohesive syndromes that are distinct from each other, shows stability over 2 years, have predictable associations with risk factors and attachment, can be distinguished from other psychiatric disorders, and cause functional impairment. Clinical trial registration information—The Bucharest Early Intervention Project, URL: http://www.clinicaltrials.gov, unique identifier: NCT00747396.

Key Words: Reactive attachment disorder, early childhood

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 This article is the subject of an editorial by Dr. Anne L. Glowinski on page 210.

 Supplemental material cited in this article is available online.

 An interview with the author is available by podcast at www.jaacap.org.

 The Bucharest Early Intervention Project was funded by the John D. and Catherine T. MacArthur Foundation through the Research Network on “Early Experience and Brain Development.”

 The authors are grateful to the research staff, children, caregivers, and families involved in the Bucharest Early Intervention Project.

 Disclosure: Drs. Gleason, Fox, Drury, Smyke, Egger, Gregas, Nelson, and Zeanah report no biomedical financial interests or potential conflicts of interest.

PII: S0890-8567(10)00948-2

doi:10.1016/j.jaac.2010.12.012

Journal of the American Academy of Child & Adolescent Psychiatry
Volume 50, Issue 3 , Pages 216-231.e3, March 2011